
Polynucleotides in Zurich
At Derma Medical Clinic, we use polynucleotides for skin that has lost smoothness or firmness—on the face, neck, or around the eyes. Whether the treatment is right for you will be clarified in a personal initial consultation.
Polynucleotides
Clarify and treat chronic abscesses and painful nodules with an experienced dermatologist at the Derma Medical Clinic in Zurich - Sihlcity
Regenerative skin therapy with biostimulating injections
Polynucleotides are biologically derived DNA building blocks that stimulate the skin to renew itself from within. They improve texture, elasticity, and moisture retention at a cellular level. The result is a gradual, visibly improved skin quality. No immediate change in shape or volume—instead, natural, subtle skin rejuvenation.
Treatment Options
Procedure
Examinations
Duration
Socially presentable after treatment
Sports, Swimming, Sauna
Cost
Gentle regeneration for your skin
A skin assessment is recommended if elasticity decreases, the skin appears thin or atrophic, fine lines—including crepey wrinkles—become visible, or the skin looks tired and lacking vitality. Especially in the lower eyelid area, a thin skin structure can indicate changes that may require treatment at an early stage.

Targeted analysis for healthy, firm skin
As part of the examination, we carefully analyse skin thickness, elasticity, and moisture levels to get an accurate picture of your skin’s condition. We also assess wrinkle patterns and tissue quality and evaluate skin type and regenerative capacity. At the same time, we clarify possible risks so the treatment can be carried out safely and tailored to you. Our specialists then determine whether treatment with polynucleotides is suitable for your skin and can achieve the desired result. If necessary, we recommend alternative measures to optimally support and strengthen your skin in the long term.
Treatment with polynucleotides
What are polynucleotides?
Polynucleotides are long-chain DNA fragments of biological origin that are used medically in purified form. They are injected directly into the skin, where they stimulate regenerative processes in the tissue—specifically: fibroblast activity, the formation of collagen and elastin, and moisture retention in the tissue. Unlike hyaluronic acid, they do not add volume; they improve the skin’s structure from the ground up.
Therapeutic approaches
Polynucleotides are introduced into the skin using thin cannulas. The treatment is carried out over several sessions, spaced a few weeks apart. The goal is a gradual improvement in skin quality from within.
Who is the treatment suitable for?
Polynucleotides are not an anti-ageing solution for everyone. They are an effective method for patients who want natural skin rejuvenation and a strengthened skin structure. For example:
- if the skin has become thinner or less elastic.
- for early skin laxity.
- for sun-damaged or mature skin.
- for sensitive lower eyelid skin.
- for skin that doesn’t calm down after heavy strain.
- if you don’t want a volumising effect, but rather a natural improvement in skin quality.
What Happens During the Examination?
Before treatment, a specialist skin analysis is carried out. The aim is to assess skin quality realistically and check whether polynucleotides are the method of choice.
- Assessment of skin structure, tissue elasticity, and wrinkle depth
- Clarification of expectations and possible alternatives
- Definition of the individual treatment plan
What happens during the treatment?
The polynucleotides are injected directly into the skin with fine needles. The procedure is performed on an outpatient basis.
- Cleansing and preparing the skin
- Injection into the previously defined areas
- Mild swelling or redness immediately afterwards is possible, but usually subsides quickly
- For optimal results, several sessions at defined intervals are planned
What sets us apart
Natural Results
The skin improves subtly and gradually. Structure, firmness, and hydration increase without changing facial features.
Experienced Doctors
Treatment is performed by specialists with experience in regenerative dermatology and modern, minimally invasive injection techniques.
High-Quality Products
We use only tested polynucleotide products whose effects and tolerability have been very well studied and are also well tolerated by sensitive skin.
Individual Consultation
We discuss whether the treatment suits your skin condition and your goals, and, if necessary, recommend alternative or combined procedures.

Procedure
Initial Consultation & Diagnosis
We analyse your skin condition and clarify whether treatment with polynucleotides makes sense—and what you can realistically expect.
Individual therapy planning
Treatment area, number of sessions, and intervals depend on your skin type and findings.
Treatment & Support
The injection is performed on an outpatient basis. You will receive clear guidance on what to look out for afterwards.
Follow-up & Adjustment
We assess progress and adjust the treatment protocol if needed.

"Naturally beautiful skin in a short time—from within. With polynucleotides."
Polynucleotides improve skin structure step by step. Book a consultation at Derma Medical Clinic. We will examine your skin and decide together whether polynucleotides are right for you.
Dr. med. univ. Martina Tröbinger is a specialist in Dermatology and Venereology (FMH) as well as Laser Medicine FMCH and holds a Laser Competence Certificate FMCH. She has many years of experience in aesthetic dermatology, with a special flair for natural results and individually tailored treatments.

What you can expect from us
Long-term support
Regenerative anti-ageing treatments require a little patience. At each session, we explain the effects to you.
Medicine and skin therapy from a single source
In all treatments, we keep your skin health in focus.
State-of-the-art therapies on site
We work with tested products that are very well tolerated by the skin.
More than just skin
Realistic, well-founded information is important to us. We want you to feel comfortable in your skin in the long term.
What patients say about our treatment
Book a consultation at Derma Medical Clinic
We will discuss the options with you and work together to determine which treatment best suits your face and your expectations.
FAQ
Frequently Asked Questions about Facial Contouring Treatment
How do polynucleotides work in the skin?
They stimulate fibroblasts, promote the formation of collagen and elastin, and improve moisture retention in the tissue. The skin structure stabilises gradually, and fine lines can soften.
Which skin areas are they suitable for?
They are commonly used on the face, neck, and décolletage and are particularly well suited for thin or sensitive skin—for example, in the lower eyelid area—as well as for sun-damaged skin or skin in need of regeneration.
What is the difference compared to hyaluronic acid?
Hyaluronic acid is used to add volume and bind moisture. Polynucleotides work differently: they biologically stimulate the tissue and improve skin quality from within. No immediate effect, but a more sustainable structural change.
Is the effect immediately visible?
The contouring is visible immediately after the injection. Slight swelling may occur in the first few days after treatment, but these are temporary. You will see the final result after about one to two weeks. Touch-ups, for example, to prolong the effect, are possible at any time as desired.
How many sessions are necessary?
Usually several sessions spaced a few weeks apart. The exact number depends on skin condition and treatment goal and is defined in the initial consultation.
When Are Initial Results Visible?
Polynucleotides work regeneratively, not immediately. The first improvements in skin quality usually appear after a few weeks and depend on skin type and individual response.



